Figure 6.

In vivo protective effect of prophylactic treatment with monoclonal antibodies (mAbs). BALB/cJ mice were given a 1:1 mixture of SA-15 and SA-17 (1 mg/kg, intraperitoneally) prophylactically and subjected to disseminated bacterial infection with USA300 Staphylococcus aureus. Kidney (A), liver (B), and heart (C) tissues were harvested after 96 hours, and bacterial load was enumerated. A significant reduction in bacterial load was observed in all 3 tissues compared with animals treated with a control immunoglobulin G preparation.