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The effects of Hippophae rhamnoides extract (HRE) on Interleukin-1β (IL-1β) and tumor necrosis factor (TNF-α) gene expression level. HREM, HRE+methotrexate (MTX); MTXG, control group that received MTX; HREG, HRE group; HG, healthy group. **P<0.001.
