Table 5.

Predictability of extrathyroidal extension

Variable		Cutoff value (cm)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC (95% CI)
BRAF (–)
Overall extrathyroidal extension	Size	0.6	60.9	59.6	42.4	75.7	0.624 (0.538–0.704)
	US group	A/B	78.3	51.1	43.9	82.8	0.633 (0.547–0.713)
Gross extrathyroidal extension	Size	0.7	100	56.1	12.1	100	0.845 (0.774–0.900)
	US group	B/C	100	60.6	13.3	100	0.777 (0.698–0.843)
BRAF (+)
Overall extrathyroidal extension	Size	0.5	56.9	64.4	64.4	56.9	0.633 (0.531–0.702)
	US group	A/B	80.4	40.0	60.3	64.3	0.599 (0.526–0.669)
Gross extrathyroidal extension	Size	0.5	61.5	73.5	26.7	92.4	0.703 (0.633–0.767)
	US group	A/B	100	33.7	19.1	100	0.666 (0.595–0.733)

PPV, positive predictive value; NPV, negative predictive value; AUC, area under the curve; CI, confidence interval; US, ultrasonography.