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. 2017 May 5;12:3521–3532. doi: 10.2147/IJN.S135749

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© 2017 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Irritation response of guinea pig abdominal skin: (A) photographs of intact skin after treatment with Speranskia tuberculata essential oil (STO)-glycerosomes for 3 consecutive days, as compared to untreated skin; (B) injured skin observed at 1 h, 24 h, 48 h, and 72 h after treatment with STO-glycerosomes; (C) histopathology images of untreated skin (left), and STO-glycerosomes-treated intact (middle) and injured (right) skin samples isolated from representative guinea pigs at magnification ×200.