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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Biochem Mol Toxicol. 2016 Oct 6;31(2):10.1002/jbt.21840. doi: 10.1002/jbt.21840

FIGURE 1.

FIGURE 1

Histological and pathological features of NASH in WT, ob/ob, and ob/ob MCD mice. Pictures of representative H&E-stained liver sections from WT, ob/ob, and ob/ob MCD mice were taken in original magnification of 20× (A). Histopathological analysis of liver from WT, ob/ob, and ob/ob MCD mice on steatosis, necrosis, inflammation, fibrosis, and biliary hyperplasia (B). Plasma collected from WT, ob/ob, and ob/ob MCD mice was analyzed for peripheral blood glucose and insulin concentrations (C). Data represent mean ± SEM. WT n = 5, ob/ob n = 5, ob/ob MCD n = 5. One-way ANOVA with Tukey’s multiple comparisons posttest were performed to determine the statistical significance. * Indicates a significant difference between ob/ob and/or ob/ob MCD with WT mice, whereas # indicates a significant difference between ob/ob and ob/ob MCD mice.