Fig. 7.

Sensitivity analysis. Bar plot of the sensitivity analysis: x axis displays the species and y axis shows sensitivity. In addition to BDNF-TrkB, calcium, calmodulin, CRTC1 and CREB show high sensitivity.

AKT, protein kinase B; BDNF, brain-derived neurotrophic factor; CAM2, Ca²⁺/calmodulin-dependent protein kinase II; CREB, cAMP response element-binding protein; CRTC1, CREB-regulated transcription coactivator 1; CTNNB1, catenin beta-1; GAD67, glutamic acid decarboxylase 67; GSK3, glycogen synthase kinase 3; NMDAR, N-methyl-D-aspartate receptor; PIP2, phosphatidylinositol 4,5-bisphosphate; PLC, phospholipase C; PPP3, protein phosphatase 3; TrkB, tropomycin related kinase B; vGAT, vesicular GABA transporter; VGLUT, vesiccular glutamate transporter.