Table 2. Associations of Oxytocin Receptor Gene (OXTR) methylation, OXTR rs53576 genotype, and stress exposure with child autistics traits at age 6 years (N = 680).

	Social Responsiveness Scale (SRS)
	SRS total			Social communication			Social cognition			Autistic mannerisms
	B (95% CI)	β	p-value	B (95% CI)	β	p-value	B (95% CI)	β	p-value	B (95% CI)	β	p-value
OXTR methylation	0.01 (-0.11; 0.14)	0.01	0.819	0.08 (-0.07; 0.23)	0.05	0.279	-0.08 (-0.27; 0.11)	-0.04	0.411	0.01 (-0.13; 0.14)	0.01	0.907
OXTR rs53576 genotype	0.002 (-0.003; 0.01)	0.03	0.392	0.002 (-0.004; 0.01)	0.03	0.497	0.004 (-0.003; 0.01)	0.04	0.267	0.000 (-0.01; 0.01)	0.002	0.951
Prenatal stress exposure	0.10 (0.05; 0.15)	0.16	< 0.001	0.10 (0.04; 0.15)	0.13	0.001	0.09 (0.02; 0.16)	0.09	0.018	0.10 (0.04; 0.15)	0.14	< 0.001
OXTR rs53576 x methylation	0.11 (0.01; 0.21)	0.08	0.038	0.12 (0.030; 0.24)	0.08	0.044	0.14 (-0.01; 0.30)	0.07	0.068	0.03 (-0.08; 0.14)	0.02	0.614

CI= confidence interval

Note. Test statistics are derived from the final block of the regression model. All analyses are adjusted for maternal smoking during pregnancy, technical covariates (i.e., the sample’s array number and position on the array), cell type proportions, child sex and age at the assessment of outcome.