Figure 3.
Densin increases the number of functional Cav1.2 channels and their relative open probability. A, Representative traces showing Igating and Itail measured at the reversal potential (+70 mV). Inset shows outward gating current on expanded timescale. Shaded area indicates Qmax. B, C, Dot plot of Qmax (B) and Itail versus Qmax (C) in cells cotransfected with Cav1.2 and eGFP (n = 9) or GFP-densin (n = 12). The fit by linear regression and coefficient of determination (r2) are shown. D–F, Same as in A–C except in cells transfected with Cav1.2ΔB1a and eGFP (n = 14) or GFP-densin (n = 14). p-values were determined by t test.