Table 2.
Potency and Efficacy of FFAR2 Agonists at Mouse FFAR2
| mFFAR2 | ||
|---|---|---|
| Calcium | ||
| Acetate | pEC50 | 2.32 ± 0.21 (n = 13) |
| pEmax | 2.27 ± 0.31 | |
| SCA14 | pEC50 | 7.80 ± 0.60 (n = 5) |
| pEmax | 3.19 ± 0.40 | |
| SCA15 | pEC50 | 5.44 ± 0.47 (n = 3) |
| pEmax | 2.01 ± 0.25 | |
| CMTB | pEC50 | NR (n = 4) |
| pEmax | ||
| CPTB | pEC50 | NR (n = 4) |
| pEmax |
pEC50 and pEmax values for each FFAR2 agonist in the calcium mobilization assays conducted in the βTC3 mouse β cell line is shown. NR refers to no response, where this indicates the absence of a calcium flux response to the agonist during a multiple concentration titration. Shown are mean ± SEM.