Table 1. Comparison of clinical information at presentation between infants with and without BA.
| Variable | Group 1 (BA Included) % or Mean (SD) N = 401 | Group (Non-BA Included) % or Mean (SD) N = 259 | p-value |
|---|---|---|---|
| Race | 0.130 | ||
| White | 244 (63%) | 156 (61.2%) | |
| Black | 61 (15.8%) | 51 (20%) | |
| Asian | 36 (9.3%) | 13 (5.1%) | |
| Other | 46 (11.9%) | 35 (13.7%) | |
| Sex | <0.001 | ||
| Male | 191 (47.6%) | 164 (63.3%) | |
| Female | 210 (52.4%) | 95 (36.7%) | |
| Ethnicity | 0.146 | ||
| Hispanic | 92 (23%) | 60 (23.3%) | |
| Non-Hispanic | 308 (77%) | 197 (76.7%) | |
| Age at First Evaluation (Days) | N = 401 | N = 259 | 0.176 |
| 63.5 (30.9) | 60 (33.3) | ||
| Age at Disease Onset (Days) | N = 401 | N = 259 | <0.001 |
| 12.8 (18.5) | 18.7 (22.1) | ||
| Weight (kg) | N = 398 | N = 257 | <0.001 |
| 4.5 (0.9) | 4.1 (1.1) | ||
| Length (cm) | N = 381 | N = 252 | <0.001 |
| 55.5 (4) | 54.3 (4.3) | ||
| Head Circumference (cm) | N = 336 | N = 215 | 0.015 |
| 37.6 (2.2) | 37.1 (2.6) | ||
| Weight Z-Score | N = 398 | N = 257 | <0.001 |
| -1 (1) | -1.5 (1.2) | ||
| Length Z-Score | N = 381 | N = 252 | <0.001 |
| -0.8 (1.5) | -1.4 (1.5) | ||
| Head Circumference Z-Score | N = 336 | N = 215 | 0.026 |
| -1.1 (1.6) | -1.4 (1.2) | ||
| Acholic Stools | <0.001 | ||
| Absent | 69 (17.6%) | 165 (66%) | |
| Present | 322 (82.4%) | 85 (34%) | |
| Acholic Stools (3 Levels) | <0.001 | ||
| Normal | 69 (17.6%) | 165 (66%) | |
| White or Gray | 184 (47.1%) | 30 (12%) | |
| Pale | 138 (35.3%) | 55 (22%) | |
| Facial Features | <0.001 | ||
| Normal | 380 (95.2%) | 207 (81.2%) | |
| Abnormal | 19 (4.8%) | 48 (18.8%) | |
| Liver Edge Palpable | 0.004 | ||
| Not Palpable | 26 (7.3%) | 34 (14.5%) | |
| Palpable | 332 (92.7%) | 201 (85.5%) | |
| Liver Edge Below Costal Margin (cm) | N = 334 | N = 202 | <0.001 |
| 3.3 (1.6) | 2.5 (1.4) | ||
| Spleen Palpable | 0.018 | ||
| Not Palpable | 188 (50%) | 149 (59.6%) | |
| Palpable | 188 (50%) | 101 (40.4%) | |
| Direct Baseline Bilirubin (mg/dL) | N = 239 | N = 162 | 0.335 |
| 5.7 (2.2) | 5.8 (3.2) | ||
| Conjugated Baseline Bilirubin (mg/dL) | N = 215 | N = 121 | 0.871 |
| 4.3 (1.6) | 4.6 (2.6) | ||
| Total Baseline Bilirubin (mg/dL) | N = 401 | N = 259 | 0.979 |
| 8.3 (3.1) | 8.6 (4.3) | ||
| AST (u/L) | N = 397 | N = 254 | 0.304 |
| 232.1 (206.4) | 284.2 (347.7) | ||
| ALT (u/L) | N = 400 | N = 255 | 0.230 |
| 154.7 (124.3) | 190.7 (232.5) | ||
| Albumin (g/dL) | N = 391 | N = 246 | 0.006 |
| 3.6 (0.5) | 3.5 (0.6) | ||
| GGTP (u/L) | N = 379 | N = 238 | <0.001 |
| 711.9 (537.5) | 299 (380.5) | ||
| Platelets (103/ mm3) | N = 380 | N = 243 | 0.022 |
| 445.2 (180.2) | 419.7 (197.3) | ||
| Alkaline Phosphatase (IU/L) | N = 395 | N = 254 | 0.230 |
| 568.6 (320.7) | 572.1 (252.1) | ||
| Total Cholesterol (mg/dL) | N = 33 | N = 54 | 0.925 |
| 184.2 (61.3) | 190.6 (82.3) | ||
| Gallbladder | <0.001 | ||
| Absent | 125 (39.9%) | 13 (6.5%) | |
| Present | 5 (1.6%) | 1 (1.4%) | |
| Present (Small) | 142 (45.4%) | 81 (40.7%) | |
| Normal | 41 (13.1%) | 105 (52.8%) | |
| Gallbladder (Absent vs. Present) | <0.001 | ||
| Absent | 125 (39.9%) | 13 (6.5%) | |
| Present | 188 (60.1%) | 186 (93.5%) |