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. 2017 May 11;12(5):e0176240. doi: 10.1371/journal.pone.0176240

Table 1. Descriptors used for advanced search in PubMed and Scopus.

Ref: References; Tox: Toxicity test; Acclim: Acclimatization period; N: number of animals per group; AB: Amount of Animals in each cage; Rand: Randomization; wk: week; d: days; M: Male; F: Female;?: not related.

Title Ref Country Animal Strain Sex Age Initial weight (g) Weight measurement Acclim Animal housing N Groups Food Intake Measurement Interval Time of diet intake Related pathology Rand Injury Lesion measurement interval
Exercise Speeds Cutaneous Wound Healing in High-Fat Diet-Induced Obese Mice Pence, et al., 2012 [35] USA C57BL/6 mice F 6 wk ? 1,3,5 days 1 wk cages 5 4 every 2 wk 10 d ? ? excisional wound 6.0-mm Daily
Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice Hiebert, et al., 2013 [36] Canada C57BL/6 mice M 7 wk & 37 wk ? ? ? cages ? 6 ? 16 d ? ? excisional wound 1cm Daily
Insulin resistance impairs cutaneous wound healing in mice Otranto, et al., 2012 [37] Brazil C57BL/6 mice M 6 wk 23–25 ? ? ? 10 2 weekly 30 wk Diabetes mellitus Yes excisional wound 1 cm2 0, 7, 14 days
Overweight induced by high-fat diet delays rat cutaneous wound healing Nascimento & Costa, 2006 [38] Brazil Wistar rat M ? 120–150 weekly ? cages 5 and 15 2 weekly 21 d ? Yes excisional wound4 cm2 Weekly
Topical fentanyl stimulates healing of ischemic wounds in diabetic rats Gupta, et al., 2015 [39] EUA ZDF Rats and Sprague–Dawley rats ? 11 wk ? ? ? ? 8 4 ? 36 d Diabetes mellitus ? excisional wound 8 mm Every two days
Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study Seitz, et al., 2015 [40] Germany C57Bl/6 (wild-type) and C57Bl/6 ob/ob F 6 wk & 12 wk 15–50 ? ? cage 4 3 ? 190 d Diabetes mellitus ? excisional wound 3-5mm 1, 3, 5, 7 and 11 days
Zucker diabetic fatty rat: A new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity Slavkovsky, et al., 2011 [41] Czech Republic ZDF rats F & M 18–20 wk 218–366 ? ? cage Males: 9–12; females: 8–10 4 ? 30 d Diabetes mellitus ? excisional wound 20mm 0, 2, 3 days
Obesity Impairs Wound Healing in Ovariectomized Female Mice Holcomb, et al., 2009 [42] USA C57BL/6 mice F 6 wk ? twice weekly ? cage 12 3 twice weekly 23 wk Ovariecto mized Mice yes excisional wound 6mm Every two days
Both obesity-prone and obesity-resistant rats present delayed cutaneous wound healing Nascimento & Costa, 2011 [43] Brasil Wistar rat M After wea-ning 30 & 60 weekly ? ? 17, 16, 17 3 Daily 22 wk Obesity Yes excisional wound 1 cm2 Weekly
Phototherapy improves wound healing in rats subjected to high-fat diet Leite, et al., 2015 [44] Brazil Wistar rat M ? 180–200 ? ? polyethylene cages 3 4 0 and 45 day 59 d ? Yes excisional wound 15-mm 0, 2, 7 and 14 days
Title Ref Country Animal Strain Sex Age Initial Weight (g) Tox Acclim Animal housing N cage ABh experimental group Groups Animal feed Treatment time Related pathology Rand Injury Lesion measurement interval Anesthesia (mg/Kg) Dose Administration (Vehicle)
Ethanol exacerbates T cell dysfunction after thermal injury Choudhrya et al., 2000 [45] USA C57BL/6 mice M 8–10 wk ? ? ? ? ? ? 4 ? ? ? yes excisional wound 15% of the total body surface area ? Sodium pentoba rbital 20% (v/v) intraperitoneal (saline)
Effect of Acute Ethanol Exposure on the DermalInflammatory Response After Burn Injury Faunce et al., 2003 [46] USA B6D2F1 mice M 8–10 wk 25–30 ? ? ? ? ? ? water ad libitum ? Bacterial infection ? burn wound14%-17% of the total body surface area (12 cm2) ? ? 20% (v/v) intraperitoneal (saline)
Acute ethanol exposure impairs angiogenesis and the proliferativephase of wound healing Radek et al., 2005 [47] USA BALB/c mice F 8–9 wk 17–21 ? ? ? ? 4 and 6 2 ? 21 d ? ? burn wound 15% of the total body surface area 7 days Nembutal 20% (v/v) intraperitoneal (saline)
Fibroblast Function and Wound Breaking Strength isImpaired by Acute Ethanol Intoxication Ranzer et al., 2011 [48] USA BALB /c mice F 6–8 wk 17 & 21 ? ? ? ? ? 2 ? 35 d ? ? excisional wound 3mm 5, 7, 10, 14, 21, 28, 35 days Ketamine—xylazine 20% (v/v) intraperitoneal (saline)
Effects of Acute Ethanol Exposure on the EarlyInflammatory Response After Excisional Injury Fitzgerald et al., 2007 [49] USA BALB/c mice F 8–9 wk ? Yes ? ? ? 3 and 5 2 ? 24 hs ? ? excisional wound 3mm 6, 12, 24 hs Nembutal ? intraperitoneal (saline)