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. 2017 May 11;12(5):e0173222. doi: 10.1371/journal.pone.0173222

Fig 4. Intramyocardial transplantation of iPSC derived CMs improves ventricular remodeling and function after myocardial infarction.

Fig 4

Hemodynamic evaluation by magnetic resonance imaging (MRI; POD 27; A+B) and conductance catheter analysis (CC; POD 28; C-F). A: Left ventricular ejection fraction (LV-EF [%]) as measured by MRI: On POD 2: Sham28 = 56±5; PBS28 = 39±5; iPSC-CM28 = 47±3. On POD 27: Sham28 = 60±4; PBS28 = 19±2; iPSC-CM28 = 34±4 B: End-diastolic volume (EDV [μl]) as measured by MRI: On POD 2: Sham28 = 34±3; PBS28 = 38±5; iPSC-CM28 = 37±2. On POD 27: Sham28 = 40±3; PBS28 = 99±9; iPSC-CM28 = 73±6 C: LV-EF (%) as measured by CC on POD 28: Sham28 = 59±1; PBS28 = 18±1; iPSC-CM28 = 33±3 D: End-diastolic volume (EDV [μl]) as measured by CC on POD 28: Sham28 = 13±1; PBS28 = 30±1; iPSC-CM28 = 21±2 E: maximum Pressure increase (ΔP/dt max. [mmHg/sec]) as measured by CC on POD 28: Sham28 = 5863±351; PBS28 = 2893±207; iPSC-CM28 = 4135±232 F: Preload adjusted maximal power (mWatts/μl2) as measured by CC on POD 28: Sham28 = 205±23; PBS28 = 20±3; iPSC-CM28 = 62±8. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001 (for group comparison); ##P<0.01; ###P<0.001; ####P<0.0001 (for paired longitudinal comparison).