Table 4. Histopathological analysis (most severe lesion) of individual prostate lobes in 8-, 12-, 16-, and 20-week-old C57BL/6 TRAMP x FVB mice1, 2.
| Prostatic intraepithelial neoplasia | Adenocarcinoma | Prostate cancer | ||||||
|---|---|---|---|---|---|---|---|---|
| n | LG | MG | HG | WD | MD | PD | (WD-PD) | |
| Anterior prostate | ||||||||
| 8-weeks | 5 | 30%a | 30% | 40% | 0% | 0% | 0%a | 0%a |
| 12-weeks | 8 | 0%b | 44% | 56% | 0% | 0% | 0%a | 0%a |
| 16-weeks | 9 | 17%a,b | 50% | 28% | 0% | 0% | 6%a | 6%a |
| 20-weeks | 12 | 8%b | 8% | 17% | 0% | 4% | 54%b | 58%b |
| Dorsal prostate | ||||||||
| 8-weeks | 5 | 0% | 50% | 50%a,b | 0% | 0% | 0%a | 0%a |
| 12-weeks | 8 | 0% | 25% | 69%a | 0% | 0% | 6%a | 6%a |
| 16-weeks | 9 | 0% | 11% | 67%a | 0% | 0% | 22%b | 22%b |
| 20-weeks | 12 | 0% | 17% | 13%b | 0% | 4% | 67%c | 71%c |
| Lateral prostate | ||||||||
| 8-weeks | 5 | 10% | 90%a | 0%a | 0% | 0% | 0%a | 0%a |
| 12-weeks | 8 | 0% | 50%b | 38%b | 0% | 0% | 13%a | 13%b |
| 16-weeks | 9 | 0% | 6%c | 39%b | 0% | 0% | 56%b | 56%c |
| 20-weeks | 12 | 17% | 4%c | 8%a | 0% | 4% | 67%b | 71%d |
| Ventral prostate | ||||||||
| 8-weeks | 5 | 40%a | 60%a | 0%a | 0% | 0% | 0%a | 0%a |
| 12-weeks | 8 | 13%a,b | 44%b | 19%b | 0% | 0% | 0%a | 0%a |
| 16-weeks | 9 | 0%b | 39%b | 6%a,b | 0% | 0% | 56%b | 56%b |
| 20-weeks | 12 | 8%b | 17%c | 0%a | 0% | 4% | 54%b | 58%c |
1Values with different letters are statistically different from one another (p < 0.05).
2LG = low-grade, MG = moderate-grade, HG = high-grade, PIN = prostatic intraepithelial neoplasia, WD = well-differentiated, MD = moderately differentiated, PD = poorly differentiated.