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. 2013 Nov 21;28(1):138–150. doi: 10.1210/me.2013-1186

Figure 6.

Figure 6.

Temporal changes of IGF-I action and its signaling during follicle growth. A, Effect of IGF-I on kitlga expression in intact follicles of EV and FG stages. The follicles at EV and FG stages were treated with IGF-I (50 ng/mL) for 6 hours. B, Expression of IGF-I receptors (igf1ra and igf1rb) at EV and FG stages. C, Responsiveness of Akt and ERK1/2 to IGF-I at EV and FG stages. The data were normalized to the housekeeping gene ef1a and expressed as the percentage of the respective control group (mean ± SEM; n = 4). **, P < .01; ***, P < .001 vs control (A) or EV stage (B).