Table 1. The genotype and allele frequencies of identified SNPs in AS cases and healthy controls.
Gene | SNP | Genotype | Case | Control | χ2 | P | Allele | Case | Control | OR (95%CI) | χ2 | P |
---|---|---|---|---|---|---|---|---|---|---|---|---|
USP34 | rs14170 | A/A | 268 | 309 | 5.346 | 0.069 | A | 810 | 861 | 1.202(1.015–1.423) | 4.560 | 0.033 |
A/G | 274 | 243 | G | 424 | 375 | |||||||
G/G | 75 | 66 | ||||||||||
rs11428092 | -/- | 282 | 261 | 3.816 | 0.148 | - | 835 | 795 | 0.857(0.725–1.013) | 3.285 | 0.070 | |
-/A | 271 | 273 | A | 397 | 441 | |||||||
A/A | 63 | 84 | ||||||||||
rs10208769 | A/A | 279 | 310 | 3.026 | 0.220 | A | 823 | 861 | 1.147(0.968–1.358) | 2.505 | 0.114 | |
A/T | 265 | 241 | T | 411 | 375 | |||||||
T/T | 73 | 67 | ||||||||||
rs2123111 | G/G | 280 | 321 | 5.335 | 0.069 | G | 823 | 875 | 1.210(1.021–1.435) | 4.829 | 0.028 | |
G/A | 263 | 233 | A | 411 | 361 | |||||||
A/A | 74 | 64 | ||||||||||
FAM161A | rs6545910 | C/C | 396 | 410 | 2.604 | 0.272 | C | 990 | 997 | 1.028(0.843–1.254) | 0.075 | 0.784 |
C/T | 198 | 177 | T | 244 | 239 | |||||||
T/T | 23 | 31 | ||||||||||
rs6748320 | G/G | 246 | 266 | 1.175 | 0.556 | G | 779 | 806 | 1.085(0.920–1.280) | 0.946 | 0.331 | |
G/A | 287 | 274 | A | 451 | 430 | |||||||
A/A | 82 | 78 | ||||||||||
rs3736598 | G/G | 253 | 270 | 0.913 | 0.634 | G | 789 | 811 | 1.076(0.912–1.270) | 0.761 | 0.383 | |
G/A | 283 | 271 | A | 445 | 425 | |||||||
A/A | 81 | 77 | ||||||||||
AHSA2 | rs777585 | T/T | 281 | 261 | 3.174 | 0.205 | T | 832 | 795 | 0.867(0.734–1.024) | 2.834 | 0.092 |
T/C | 270 | 273 | C | 400 | 441 | |||||||
C/C | 65 | 84 | ||||||||||
B3GNT2 | rs3811616 | A/A | 365 | 357 | 0.328 | 0.849 | A | 946 | 940 | 0.967(0.803–1.164) | 0.127 | 0.722 |
A/G | 216 | 226 | G | 288 | 296 | |||||||
G/G | 36 | 35 | ||||||||||
C2orf74 | rs1729674 | T/T | 266 | 303 | 4.490 | 0.106 | T | 803 | 853 | 1.195(1.011–1.414) | 4.339 | 0.037 |
T/G | 271 | 247 | G | 431 | 383 | |||||||
G/G | 80 | 68 | ||||||||||
COMMD1 | rs55785307 | C/C | 334 | 342 | 0.435 | 0.804 | C | 911 | 925 | 1.055(0.880–1.263) | 0.332 | 0.564 |
C/G | 243 | 241 | G | 323 | 311 | |||||||
G/G | 40 | 35 | ||||||||||
KIAA1841 | rs1177284 | G/G | 195 | 222 | 3.458 | 0.177 | G | 692 | 716 | 1.070(0.913–1.256) | 0.701 | 0.403 |
G/A | 302 | 272 | A | 538 | 520 | |||||||
A/A | 118 | 124 | ||||||||||
__ | rs10865331 | G/G | 178 | 216 | 10.084 | 0.006 | G | 628 | 710 | 1.303(1.111–1.526) | 10.678 | 0.001a |
G/A | 272 | 278 | A | 606 | 526 | |||||||
A/A | 167 | 124 |
SNP, Single nucleotide polymorphism
a P-value remained statistically significant after Bonferroni correction.