Table 3. INL, OPL, ONL, and IRL volumes and thicknesses in ETDRS grid for each group.
| INL | OPL | ONL | IRL | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | no-DR | mild DR | Control | no-DR | mild DR | Control | no-DR | mild DR | Control | no-DR | mild DR | |
| Average volume, mm | 0.99 ± 0.08 | 1.00 ± 0.08 | 1.00 ± 0.09 | 0.84 ± 0.09 | 0.81 ± 0.08# | 0.86 ± 0.09# | 1.63 ± 0.19 | 1.61 ± 0.17 | 1.61 ± 0.19 | 6.35 ± 0.36* | 6.25 ± 0.36* | 6.32 ± 0.36 |
| EDTRS, μm | ||||||||||||
| Central fovea subfield | 18.5 ± 6.9 | 19.8 ± 7.6 | 20.7 ± 6.0 | 25.4 ± 7.5 | 25.7 ± 7.8 | 27.6 ± 8.5 | 86.4 ± 12.6 | 83.1 ± 11.5 | 84.8 ± 14.3 | 171 ± 21 | 168 ± 19 | 174 ± 22 |
| Inner 3-mm subfield | 40.5 ± 4.1 | 41.2 ± 3.7 | 41.1 ± 4.1 | 35.3 ± 5.5* | 33.8 ± 4.6*# | 37.0 ± 6.2# | 65.5 ± 8.8 | 65.8 ± 7.8 | 65.0 ± 9.2 | 252 ± 14 | 250 ± 16 | 251 ± 14 |
| Superior | 41.1 ± 4.7 | 41.6 ± 4.4 | 41.6 ± 4.7 | 35.4 ± 10.7 | 34.0 ± 8.2# | 39.0 ± 12.0# | 64.7 ± 13.2 | 65.2 ± 11.0 | 63.4 ± 14.2 | 257 ± 15 | 254 ± 17 | 255 ± 13 |
| Inferior | 41.0 ± 4.7 | 41.8 ± 4.5 | 41.0 ± 5.1 | 35.7 ± 10.1 | 33.7 ± 8.9 | 35.5 ± 9.0 | 62.7 ± 15.0 | 62.8 ± 11.1 | 63.0 ± 13.5 | 253 ± 15 | 251 ± 17 | 251 ± 16 |
| Temporal | 38.1 ± 5.2 | 39.2 ± 4.3 | 38.8 ± 4.1 | 31.3 ± 6.2 | 31.9 ± 7.3 | 31.9 ± 6.7 | 69.2 ± 10.4 | 68.5 ± 9.2 | 70.8 ± 11.0 | 244 ± 15 | 241 ± 17 | 245 ± 15 |
| Nasal | 41.8 ± 5.5 | 42.1 ± 5.0 | 42.9 ± 5.9 | 38.0 ± 10.3 | 35.6 ± 10.3# | 41.7 ± 13.2# | 65.1 ± 14.8 | 66.6 ± 12.9 | 62.6 ± 15.1 | 254 ± 15 | 253 ± 16 | 254 ± 16 |
| Outer 6-mm subfield | 34.3 ± 3.0 | 34.0 ± 2.9 | 34.4 ± 3.2 | 28.0 ± 3.0 | 27.3 ± 2.5# | 28.6 ± 2.6# | 54.2 ± 6.6 | 53.3 ± 6.0 | 53.8 ± 6.4 | 219 ± 14* | 215 ± 13* | 217 ± 11 |
| Superior | 33.3 ± 3.5 | 33.4 ± 3.8 | 33.9 ± 4.2 | 26.9 ± 4.0 | 26.0 ± 4.1# | 26.8 ±2.9# | 57.3 ± 7.3 | 56.7 ± 6.7 | 56.5 ± 5.9 | 221 ± 17* | 217 ± 13* | 220 ± 12 |
| Inferior | 33.3 ± 4.4 | 32.9 ± 4.2 | 33.1 ± 3.9 | 27.2 ± 4.0 | 26.7 ± 4.1 | 26.8 ± 2.7 | 50.9 ± 8.8 | 49.3 ± 6.3 | 50.3 ± 8.4 | 209 ± 14 | 205 ± 14 | 208 ± 13 |
| Temporal | 34.2 ± 3.0 | 33.8 ± 2.8 | 33.6 ± 3.1 | 27.0 ± 3.2 | 26.4 ± 2.7 | 26.9 ± 2.7 | 56.0 ± 8.0 | 54.8 ± 5.9 | 56.4 ± 8.0 | 206 ± 16 | 203 ± 14 | 206 ± 14 |
| Nasal | 36.6 ± 3.8 | 36.0 ± 3.7 | 36.9 ± 4.9 | 30.9 ± 5.1 | 30.1 ± 4.6# | 32.8 ± 5.7# | 52.9 ± 8.9 | 52.4 ± 8.5 | 52.0 ± 8.7 | 237 ± 16 | 233 ± 16 | 234 ± 22 |
All of the values are presented as the mean ± SD (μm). The inner subfield thickness is an average of the four parafoveal sectors, and the outer subfield is an average of the four perifoveal sectors. Bold values indicate statistically significant differences among the three groups by ANOVA. The characters “*” and “#” indicate significant differences by Bonferroni’s post hoc test (P<0.05) between the no-DR and control groups, and between the no-DR and mild DR groups, respectively. INL: inner nuclear layer, OPL: outer plexiform layer (OPL), ONL: outer nuclear layer, IRL: inner retina layer