Top: Linear arena in which a rat moves, with indicated locations of 5 place cells (color coded green, yellow, orange, red, and maroon in order.). The place cells are representatives of 5 neuronal ensembles (colored clouds), each active in one of the five locations on the arena. The neuronal ensembles each send a single axonal projection in spatial order to a small dendritic segment on a postsynaptic neuron, with an average spacing S between connected spines. Note that spines need not be immediately adjacent to each other. Below, buildup of reactant following input activity with the appropriate timing, corresponding to the rat moving at a speed which the dendritic chemistry recognizes.
DOI:
http://dx.doi.org/10.7554/eLife.25827.002