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. 2017 Mar 31;38(6):3052–3068. doi: 10.1002/hbm.23573

Table 3.

Comparison of the whole‐brain volume and the whole‐brain mean ADC values in our atlases and published findings referring to individual subjects

W1‐2 Rest Q1 Q2 Q3 Q4 Y2 Y3 Y4 Y5 Y6 Adult (20–40 yo) Imaging protocol
Whole‐brain volume
Male individuals 506 ± 96 609 ± 71 799 ± 130 922 ± 72 1,003 ± 99 1,192 ± 143 1,297 ± 179 1,347 ± 145 1,370 ± 62 1,383 ± 149 Siemens 3T, 23 mm
Female individuals 460 ± 22 575 ± 61 681 ± 161 908 ± 52 984 ± 93 1,040 ± 123 1,176 ± 110 1,244 ± 106 1,288 ± 124 1,328 ± 90
P values (male = female) 0.23 0.22 0.15 0.37 0.37 0.002 0.029 0.048 0.025 0.12
Constructed atlases 496 599 767 929 1,006 1,120 1,267 1,289 1,317 1,364
P values (population mean = atlas mean) 0.52 0.52 0.70 0.79 0.65 0.52 0.75 0.33 0.44 0.62
Huang et al., 2006 367 ± 18 1,258 ± 86 Phillips 1.5T, 1.83 mm
Knickmeyer et al., 2008 425 855 983 Siemens 3T, 13 mm (T1)
Gilmore et al., 2007 (males) 525 Siemens 3T, 13 mm (T1)
Gilmore et al., 2007 (females) 487 Siemens 3T, 13 mm (T1)
Watanabe et al., 2013 (males) ∼520 ∼1,350 ∼1,400 Phillips 1.5T, 2 × 3 × 5 mm
Watanabe et al., 2013 (females) 500 ∼1,200 ∼1,200 Phillips 1.5T, 2 × 3 × 5 mm
Whole‐brain mean ADC
Male individuals 1,377 ± 50 1,319 ± 177 1,163 ± 14 1,109 ± 21 1,067 ± 29 1,043 ± 42 1,003 ± 31 1,003 ± 26 978 ± 18 975 ± 26 Siemens 3T, 23 mm
Female individuals 1,467 ± 118 1,274 ± 58 1,204 ± 42 1,085 ± 29 1,069 ± 18 1,025 ± 35 1,011 ± 17 1,001 ± 23 976 ± 35 967 ± 36
P values (male = female) 0.06 0.32 0.06 0.14 0.45 0.10 0.22 0.41 0.45 0.22
Constructed atlases 1,385 1,290 1,202 1,096 1,068 1,039 1,006 1,001 974 968
P values (population mean = atlas mean) 0.25 0.37 0.92 0.55 0.51 0.75 0.49 0.40 0.50 0.29
Watanabe et al ∼1,220 ∼860 ∼760 Phillips 1.5T, 2 × 3 × 5 mm

Bold values indicate our result. The unit for b values is s/mm2. In the far right column, the imaging modality is diffusion imaging by default; modalities that are not diffusion imaging are noted in the bracket [e.g., (T1) means T1‐weighted MRI]. For diffusion imaging, b = 1,000 s/mm2 unless otherwise noted. Gray bars are results in our cohort (comparing males versus females, individuals versus atlases). P values indicating statistical significant differences (P < 0.05) are in italics.