Table 4.
Tacrolimus dose-adjusted trough concentrations in adults and children across genotypes 1 year after kidney transplantation
| Genotype | Tacrolimus trough (C0/D; ng/mL/mg) [median (range)] | No. of patients | p value (Wilcoxon rank-sum test) |
|---|---|---|---|
| Adults | |||
| CYP3A5 | |||
| *1/*1 and *1/*3 | 1.03 (0.25–3.27) | 6 | |
| *3/*3 | 4.53 (0.88–11.4) | 31 | 0.0017 |
| PPARA | |||
| G/G | 3.4 (0.25–7.5) | 20 | |
| G/A + A/A | 3.2 (0.74–11.4) | 17 | 0.55 |
| POR | |||
| *1/*1 | 3.53 (0.74–11.4) | 19 | |
| *1/*28 + *28/*28 | 3.23 (0.25–7.5) | 18 | 0.94 |
| CYP3A4 | |||
| *1/*1 | 3.23 (0.88–11.4) | 36 | |
| *1/*22 | 3.53 | 1 | NA |
| Children | |||
| CYP3A5 | |||
| *1/*1 and *1/*3 | 1.69 (0.60–2.0) | 4 | |
| *3/*3 | 2.79 (1.73–5.4) | 14 | 0.0107 |
| PPARA | |||
| G/G | 2.2 (1.48–5.0) | 9 | |
| G/A + A/A | 2.3 (0.6–5.4) | 9 | 0.83 |
| POR | |||
| *1/*1 | 2.2 (0.6–5.0) | 15 | |
| *1/*28 + *28/*28 | 2.32 (2–5.4) | 3 | 0.41 |
| CYP3A4 | |||
| *1/*1 | 2.2 (0.6–5.4) | 17 | |
| *1/*22 | 3.5 | 1 | NA |
CYP cytochrome P450, NA not applicable, POR cytochrome P450 oxidoreductase, PPARA peroxisome proliferator-activated receptor-alpha