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. 2017 May 12;7:175. doi: 10.3389/fcimb.2017.00175

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Copyright © 2017 Zheng, Chen, Wang, Fan, Feng, Gao and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DV1- and DV2-specific antibody responses in mice immunized with the bivalent vaccine (n = 5). Sera were collected two weeks after the third immunization. (A) End-point titers of anti-DV1 and anti-DV2 IgG assayed by ELISA. The results were recorded as GMT + SD. (B) End-point titers of anti-DV1 and anti-DV2 NAb assayed by PRNT₅₀. The results were recorded as GMT + SD. ^*p < 0.05, ^**p < 0.01.