FIGURE 6.

Effects of external pH on the dialysis activated Cl^– current in HVCN1^–/– neutrophils (n = 3). Typical examples (n = 3). Black traces pH 7.3, blue traces pH 5.7, red traces pH 9.0. Experiments were carried out in solution set E (Table 1). (A) The reversal potential (–31 mV) is insensitive to pH. (B) Full IVs: pH has only minor effects on the current amplitude. (C) In low Cl^– concentration solution (10 mM), outward rectification is seen at high pH (red trace), inward rectification at low pH (blue trace). The brown trace represents pH 7.3, 10mM Cl^– solution. The black trace represents pH 7.3 at normal Cl^– concentration.