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. 2017 May 12;8:262. doi: 10.3389/fphar.2017.00262

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Copyright © 2017 Behe, Foote, Levine, Platt, Chou, Benavides, Geha and Segal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tamoxifen does not counteract the oxidase-driven alkalinization and swelling of the vacuole. (A) Distribution SNARF fluorescence ratios measured in a minimum of 700 fully phagocytosed SNARF-labeled Candida by human neutrophils. Fluorescence ratios are indicated on the left-hand side, a corresponding pH scale is provided on the right-hand side (see Materials and Methods for calibration of SNARF fluorescence ratio to pH). (B) Distribution of areas measured in a minimum of 340 individual vacuoles incorporating a single Candida. Boxes show medians and interquartile ranges of data, compiled from three independent experiments. Red circles locate the mean values, the asterisk locating the mean for DPI denotes statistical significance from the control p < 0.05.