Fig. 6.

Validation of the EP300 signature in other cell models. a QPCR data from EP-downregulated minimally transformed mammary epithelial cells, and their paclitaxel-resistant derivatives. The gene set is the same that is used in Fig. 5c to validate the MCF-7 signature. b QPCR data of anti-apoptotic BCL2 and stem cell marker ABCG2 from the MCF-7 signature in HCT116 cells. c and d, Bcl-2 immunoblot (top panels) and blot quantification (lower panels) in both MCF-7 (c) and HCT116 (d) cell derivatives. β-actin is used as a loading control. Numerical data represent the average ± SD of three independent experiments. All statistical comparisons (*P < 0.05) versus control cells. Immunoblot shows a representative of three independent experiments