Table 1.
Modulation of paclitaxel sensitivity after experimental modulation of EP300 expression in cell models
| Cell type | Cell derivative | EP300 status | IC50 (nM)a | Fold resistance | Fold sensitivity |
|---|---|---|---|---|---|
| MCF7 | MCF7-shev | 1.3 | |||
| MCF7-shEP300-1 | Downregulated | 5.0 | 3.8 | ||
| MCF7-shEP300-2 | Downregulated | 7.5 | 5.7 | ||
| MCF7-shEP300-1-TX | Downregulated | 45.6 | 35.1 | ||
| MCF7-shEP300-2-TX | Downregulated | 29.6 | 22.7 | ||
| HCT116 | HCT116 | 3.1 | |||
| HCT-KOEP300 | Knockedout | 14.2 | 4.6 | ||
| HCT-KOEP300-TX | Knockedout | 53.0 | 17.1 | ||
| CAL51 | CAL-ev | 4.2 | |||
| CAL-EP300 | Upregulated | 1.8 | 2.3 | ||
| MDA-MB-231 | MDA-ev | 32.1 | |||
| MDA-EP300 | Upregulated | 9.2 | 3.5 |
aPaclitaxel concentration at which proliferation after 3 days was reduced by 50% estimated from the corresponding dose–response curves