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. 2017 Jan 25;83(6):1263–1272. doi: 10.1111/bcp.13214

Table 4.

Correlations between reported dose and extrapolated 4‐h plasma paracetamol concentrations, APAPpl:APAPt ratio, and markers of organ injury in patients receiving acetylcysteine within 8 h of overdose

Peak serum aminotransferase concentration, IU l −1 Peak INR Peak serum creatinine, μmol l −1
r 95% CI P r 95% CI P r 95% CI P
Reported dose, mg 0.153 0.025−0.276 0.02 −0.040 −0.167−0.089 0.53 0.108 −0.021−0.233 0.09
Extrapolated 4‐h plasma concentration, mg l −1 0.184 0.059−0.304 0.003 0.271 0.150−0.385 <0.0001 −0.029 −0.155−0.098 0.65
APAP pl :APAP t 0.185 0.060−0.305 0.003 0.269 0.232−0.391 <0.0001 −0.027 −0.153−0.100 0.67