Figure 8.

Possible models for the functions of TaRecJ1 and TaRecJ2 in the T. acidophilum cells. TaRecJ2 is present in the CMG-like replicative helicase complex through the interaction with the TaGins51-B-domain, although there is no interaction between TaRecJ2 and TaMCM (left). TaRecJ1 may function as the counterpart of bacterial RecJ (middle and right) in the stalled replication fork repair process. If DNA polymerase encounters a lesion on the leading strand template, for example, the replication fork is halted with the extended lagging strand (middle). TaRecJ1 may degrade Okazaki fragments in coordination with Hjm (right) followed by fork regression to process the repair.