Figure 1.

Experimental tooth movement by orthodontic force. A, illustration of the method by which the upper first molar tooth was moved by means of orthodontic force. The arrow indicates the direction of orthodontic force. B, after the experimental tooth movement, the maxillary bones of WT and KO mice were analyzed using μCT. The panels show typical images. The arrows (black and white) indicate the spaces caused by tooth movement. R, right side with mechanical loading; L, left side without mechanical loading. C, the movement distance between the first molar and the second molar was measured from digital μCT images. WT males, n = 6; KO males, n = 5; WT females, n = 5; KO females. n = 4. *, p < 0.05; **, p < 0.01.