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. 2017 Mar 21;7(5):1451–1461. doi: 10.1534/g3.117.040535

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Copyright © 2017 Baines et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of increase in myofilament disorganization with age, for each unc-68 variant. The whole-body scores for extent of disorganization of the sarcomeric structure from 0 to 14 d of adulthood are presented for the strain transgenic for wild-type unc-68 (UL4140) (A), and strains transgenic for unc-68 with amino acid changes equivalent to RyR1 variants associated with: MH in blue (G341R (B), R2454H (C), R2163H (E), and R2458H (F); EHI in red (R163C) (D); CCD in green (A4940T) (G) and (R4861H) (H); and LOAM in purple (K3452Q) (I). Each boxplot represents the median, interquartile range, and minimum and maximum for the whole-body scores.