Table 3.

Association of FTO SNPs with anthropometric characteristics, adipokines, ghrelin and TNF-α in GDM patients

FTO rs8050136/ rs9939609	CC/ TT	CA and AA/ TA and AA	P value	P corr
Pre-pregnancy weight (kg)	72 (60–79)	70.5 (63.5–79.6)	0.729	0.804
Pre-pregnancy BMI (kg/m2)	30 (26.9–33.2)	29.8 (26.3–32.1)	0.805	0.901
Gestational weight gain (kg)	6.3 (2.8–10.0)	8.5 (3.6–12.5)	0.283	0.352
Fasting glucose (mg/dL)	101.5 (88.7–123.6)	90.4 (76.1–119.5)	0.313	0.319
Insulin (μIU/mL)	19.2 (7.5–32.8)	17.3 (4.4–35.8)	0.951	0.986
HOMA-IR	4.1 (1.9–10.2)	4.0 (4.0–10.9)	0.671	0.772
Leptin (ng/mL)	19.9 (15.8–26.9)	15.5 (13.4–23.1)	0.211	0.169
Adiponectin (ng/mL)	10.1 (7.3–11.2)	5.5 (3.8–7.8)	0.043	0.048
Ghrelin (pg/mL)	626.1 (487.7–728.8)	618.7 (505.9–690.3)	0.864	0.654
TNF-alpha (pg/mL)	10.0 (9.0–11.9)	12.8 (10.1–13.2)	0.040	0.043

FTO rs1421085	TT	TC and CC
Pre-pregnancy weight (kg)	74 (63.5–80)	70.0 (62.5–82.9)	0.894	0.902
Pre-pregnancy BMI (kg/m2)	30.7 (27.0–34.0)	28.6 (25.8–32.2)	0.583	0.632
Gestational weight gain (kg)	6.0 (2.0–10.0)	9.0 (5.5–13.5)	0.004	0.012
Fasting glucose (mg/dL)	100.2 (87.9–123.5)	90.9 (75.6–119.9)	0.651	0.775
Insulin (μIU/mL)	19.5 (7.9–36.8)	16.6 (4.2–40.6)	0.846	0.942
HOMA-IR	5.2 (2.1–11.5)	4.0 (0.86–11.7)	0.898	0.875
Leptin (ng/mL)	20.6 (16.5–24.5)	14.7 (13.3–22.4)	0.462	0.563
Adiponectin (ng/mL)	9.7 (6.8–11.2)	6.6 (4.3–9.0)	0.101	0.223
Ghrelin (pg/mL)	626.1 (489.9–735.4)	574.0 (494.2–638.6)	0.419	0.532
TNF-alpha (pg/mL)	9.8 (9.0–11.7)	12.0 (10.0–13.0)	0.048	0.05

Data are expressed as median (interquartile range 25–75%)

SNPs single nucleotide polymorphisms, GDM gestational diabetes mellitus, FTO fat mass and obesity associated gene, BMI body mass index, HOMA-IR homeostasis model assessment index

P corr, adjusted for age and pre-gestational body weight