Table 3.

The level of 8-oxo-dG in human serum and cytogenetic damage in human lymphocytes in accordance with lycopene plus β-carotene concentration

		Dose (Gy)	Baseline	Intake	Washout
			Mean ± SE	Mean ± SE	Mean ± SE
8-oxo-dG	(A)	0	0.46 ± 0.23	0.32 ± 0.10	0.28 ± 0.10
(ng/mL)		0.1	0.66 ± 0.30	0.52 ± 0.21	0.74 ± 0.35
		0.5	0.58 ± 0.30	0.42 ± 0.20	0.48 ± 0.09
		2	0.41 ± 0.19	0.34 ± 0.08	0.49 ± 0.17
	(B)	0	0.73 ± 0.22	0.45 ± 0.08	0.97 ± 0.46
		0.1	0.71 ± 0.21	0.53 ± 0.04	0.76 ± 0.29
		0.5	0.45 ± 0.11	0.53 ± 0.12 b	1.04 ± 0.21
		2	0.63 ± 0.20	0.77 ± 0.30	0.69 ± 0.20
MN	(A)	0	22.10 ± 2.96	17.93 ± 4.45	24.07 ± 4.34
(/1000 BNC)		0.1	22.86 ± 1.93	20.54 ± 1.78	28.91 ± 3.59
		0.5	68.98 ± 8.04	54.88 ± 4.87	57.05 ± 8.38
		2	281.6 ± 15.6	330.7 ± 26.7	337.9 ± 19.9
	(B)	0	20.17 ± 2.97	14.30 ± 3.07	24.94 ± 5.63
		0.1	22.43 ± 6.45	20.84 ± 4.32	24.27 ± 3.79
		0.5	57.84 ± 7.61	50.06 ± 4.06	53.01 ± 4.19
		2	286.6 ± 12.2	300.2 ± 26.7	282.6 ± 17.8
DIC	(A)	0	0	0.18 ± 0.18	0
(/500 metaphase)		0.1	0.92 ± 0.49	0.38 ± 0.23	0.78 ± 0.20
		0.5	21.31 ± 1.33	19.93 ± 0.87	21.1 ± 1.71
		2	98.72 ± 6.24	93.47 ± 4.32	105.4 ± 7.1
	(B)	0	0.19 ± 0.19	0	0.19 ± 0.19
		0.1	0.32 ± 0.32	0.58 ± 0.39	0.40 ± 0.24
		0.5	18.65 ± 1.86	14.99 ± 1.31 a,#	20.86 ± 1.96
		2	89.45 ± 6.13	85.64 ± 3.26 $	99.73 ± 5.60

(A) Group of individuals where the lycopene plus β-carotene concentration was higher than the median value at baseline (>0.635 μg/mL). N = 5 (1 male, 4 females) (B) Group of individuals where the lycopene plus β-carotene concentration was less than the median value at baseline (<0.635 μg/mL). N = 5 (4 males, 1 female) Values are given as mean ± SE of five donors. a: different from the baseline (P < 0.05), b: different from the washout period (P < 0.05), #: different from the washout (P = 0.056), $: different from the washout (P = 0.056) by Wilcoxon signed-ranks test (8-oxo-dG) and paired t test (MN and DIC)