Table 1.

Description of participants with preserved spirometry identified as high symptom burden by two different methods (n = 880)

	Identified by CAT ≥10 points (n = 456)	Identified by Respiratory Questions of CAT ≥7 points (n = 403)	P Value
Demographics
Age, yr, mean (SD)	59.4 (9.9)	59.1 (9.7)	0.74
Female sex, %	55.7	56.6	0.78
African American race, %	33.8	33.5	0.92
BMI, kg/m2, mean (SD)	29.8 (5.4)	29.8 (5.4)	1
Smoking history
Pack-years, mean (SD)	46.1 (26.4)	45.8 (26.6)	0.59
Currently smoking, %	57.2	58.3	0.74
Lung function
FEV1, L, mean (SD)	2.61 (0.70)	2.61 (0.70)	1
FEV1, % predicted, mean (SD)	92.0 (14.7)	92.2 (14.0)	0.38
Comorbid conditions, %
Obesity (BMI ≥30 kg/m2)	48.7	48.1	0.85
Asthma	27.6	29.3	0.58
Diabetes	19.3	19.1	0.94
Coronary artery disease	5.9	5.7	0.99
Markers of respiratory impact, %
Any respiratory event prior to enrollment	22.8	24.6	0.53
Chronic bronchitis symptoms*	30.9	35.0	0.20
mMRC dyspnea score ≥2†	25.9	26.8	0.76
Short distance during 6-min walk test‡	22.4	23.1	0.81
Impaired quality of life measured by SGRQ total score§	66.9	70.5	0.25
Any of the above	80.7	83.6	0.26
CAT score, mean (SD)	17.9 (6.4)	18.3 (6.7)	0.20

Definition of abbreviations: BMI = body mass index; CAT = COPD Assessment Test; mMRC = modified Medical Research Council dyspnea scale; SGRQ = St. George’s Respiratory Questionnaire.

P value represents comparison of means or proportions among those identified by each strategy.

^*Chronic bronchitis was defined as cough and phlegm production for at least 3 consecutive months per year for at least 2 years.

^†Dyspnea was defined as mMRC score greater than or equal to 2.

^‡Short walking distance was defined as distance walked in 6 minutes less than 250 m.

^§Impaired quality of life was defined as an SGRQ total score greater than 25.