Table 2.

Use of two strategies used to identify subjects with high symptom burden to predict quality of life, physical activity, and exacerbations (n = 880)

	CAT ≥10 points AUC (95% CI)	Respiratory Questions of CAT ≥7 points AUC (95% CI)	P Value
Cross-sectional associations
Any respiratory event prior to enrollment	0.66 (0.62–0.70)	0.67 (0.63–0.71)	0.77
Dyspnea*	0.70 (0.67–0.74)	0.69 (0.66–0.73)	0.59
Short distance in 6-min walk test†	0.62 (0.58–0.66)	0.62 (0.57–0.66)	0.86
Impaired quality of life measured by SGRQ total score‡	0.81 (0.79–0.83)	0.81 (0.78–0.83)	0.87
Longitudinal exacerbations (during 1-yr follow-up)
Any	0.66 (0.61–0.70)	0.65 (0.60–0.70)	0.69
Any requiring steroids or antibiotics	0.65 (0.60–0.70)	0.65 (0.60–0.71)	0.76
Any requiring health-care use	0.65 (0.60–0.69)	0.64 (0.58–0.69)	0.58

Definition of abbreviations: AUC = area under the receiver operating characteristic curve; CAT = COPD Assessment Test; CI = confidence interval; SGRQ = St. George’s Respiratory Questionnaire.

P value is for the comparison of AUCs.

^*Dyspnea was defined as modified Medical Research Council dyspnea scale score greater than or equal to 2.

^†Short walking distance was defined as distance walked in 6 minutes less than 250 m.

^‡Impaired quality of life was defined as SGRQ total score higher than 25.