Table 2. EASL-EORTC recommendations with further revisions of non-invasive diagnostic criteria of HCC.

2001	Diagnosis of HCC larger than 20 mm on basis of strong enhancement after intravenous contrast agent administration in HAP in two out of four following imaging modalities: multiphase CT, DCE-MRI, angiography and CEUS or in one mentioned imaging modality if the AFP serum levels exceeded 400 ng/mL.
2005	• Introduction of a new radiological enhancement pattern of HCC - a strong uptake of contrast agent in HAP and its subsequent wash-out in PVP/EP,      • Diagnosis of HCC measuring 10 to 20 mm required confirmation of the typical enhancement pattern in two imaging modalities (multiphase CT, DCE-MRI and CEUS),      • Diagnosis of HCC larger than 20 mm - confirmation in one imaging modality,      • Removal of evaluation of serum APF level from diagnostic algorithm.
2012	• Exclusion of CEUS from diagnostic algorithm,      • Confirmation of the efficacy and maintenance the other criteria for the diagnosis of HCC in multiphase CT, DCE-MRI.

AFP - alpha-fetoprotein, CEUS - contrast enhanced ultrasonography, CT - computed tomography, DCE-MRI - dynamic contrast-enhanced magnetic resoanace imaging, EP - equilibrium phase, HAP - hepatic arterial phase, HCC - hepatocellular carcinoma, PVP - portal venous phase.