Table 2.

Statistical analysis of proteins in a given protein family^a that display the strand-loop-helix motif with the corresponding Cys in a “forbidden” conformation

Important families	Pfam accession	Percentage of proteins in the Pfam family with structural motif	Experimental Information oxidationb	Reference
Y_phosphatase	PF00102	70,27	Yes	(Yang et al. 2007; Sivaramakrishnan et al. 2005)
Glutamine amidotransferase (GATase)	PF00117	69,56	No
Rhodanese-like domain	PF00581	37,50	Yes	(Seo and Carroll 2009)
Dual specificity phosphatase	PF00782	30,77	Yes	(Alonso et al. 2004; Eiamphungporn et al. 2009)
Carbon–nitrogen hydrolase	PF00795	91,67	No
SNO glutamine amidotransferase	PF01174	83,33	Yes (ortholog)	(Wolf et al. 2008)
DJ-1/PfpI	PF01965	68,75	Yes	(Canet-Avilés et al. 2004; Wilson et al. 2004; Wolf et al. 2008)

^aAs defined by the Pfam HMM model; for more information, see Sonnhammer et al. (1997)

^bExperimental information on cysteine oxidation which has been reported in any member of the Pfam family