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. 2017 Mar 7;7:107. doi: 10.1038/s41598-017-00151-6

Figure 2.

Figure 2

Impaired transcriptional response with the loss of MAPL. (A) Mapl fl/fl and Mapl −/− MEFs were left untreated or infected with Sendai virus (150 HAU/mL) for 3 or 6 hours, RNA was extracted, and Nf-kB, IL6, IFNα1, IFNβ1, RIG-I, MDA5, IFIT1 and IFIT2 levels were measured by quantitative real-time PCR (n = 3). (B) MEFs were left untreated or infected with Sendai virus (150 HAU/mL) for 18 or 36 hours, RNA was extracted, and Sendai virus Protein P level was measured by quantitative real-time PCR (n = 3). Results are expressed as the median induction, comparing Mapl −/− to Mapl fl/fl. *P < 0.05, **P < 0.01 and ***P < 0.001, n.s., nonsignificant.