Table 2.
Main enzymatic and metabolic pathways associated with the up-regulated and down-regulated proteins in ganetespib-treated 5637 cells as analyzed by the Kyoto Encyclopedia of Genes and Genomes (KEGG).
| Biological pathway | % | P-value |
|---|---|---|
| ≥Twofold up-regulated proteins | ||
| Steroid biosynthesis | 0.7 | 2.3 × 10−4 |
| Regulation of actin cytoskeleton | 2.7 | 4.3 × 10−4 |
| Ubiquitin mediated proteolysis | 2.1 | 1.1 × 10−3 |
| Endocytosis | 2.2 | 1.6 × 10−3 |
| Adherens junction | 1.2 | 3.8 × 10−3 |
| N-Glycan biosynthesis | 0.8 | 1.4 × 10−2 |
| SNARE interactions in vesicular transport | 0.8 | 1.5 × 10−2 |
| Valine, leucine and isoleucine biosynthesis | 0.4 | 2.1 × 10−2 |
| Phosphatidylinositol signaling system | 1.0 | 2.3 × 10−2 |
| ErbB signaling pathway | 1.1 | 2.5 × 10−2 |
| Inositol phosphate metabolism | 0.8 | 3.1 × 10−2 |
| Terpenoid backbone biosynthesis | 0.4 | 4.9 × 10−2 |
| Pantothenate and CoA biosynthesis | 0.4 | 4.9 × 10−2 |
| ≥Twofold down-regulated proteins | ||
| Oxidative phosphorylation | 2.5 | 1.1 × 10−8 |
| Pyrimidine metabolism | 2.1 | 3.8 × 10−8 |
| Purine metabolism | 2.2 | 4.6 × 10−5 |
| Notch signaling pathway | 1.0 | 1.3 × 10−4 |
| RNA polymerase | 0.8 | 1.9 × 10−4 |
| Spliceosome | 1.8 | 2.7 × 10−4 |
| Basal transcription factors | 0.6 | 2.1 × 10−2 |
| Pathways in cancer | 2.7 | 2.6 × 10−2 |
| Cell cycle | 1.3 | 3.4 × 10−2 |
| Glutathione metabolism | 0.7 | 3.9 × 10−2 |
| Nucleotide excision repair | 0.6 | 4.3 × 10−2 |
| Bladder cancer | 0.6 | 4.8 × 10−2 |
| DNA replication | 0.6 | 4.9 × 10−2 |