Table 5.
Summary of post-translational modifications (PTMs) identified on the core histones in AUY922- and ganetespib-treated bladder cancer 5637 cells.
| Histone PTM type | Total histone mark | Novel histone mark |
|---|---|---|
| Acetylation | 16 | 1 |
| Butyrylation | 2 | 1 |
| Citrullination | 6 | 6 |
| 2-Hydroxyisobutyrylation | 1 | 1 |
| Malonylation | 1 | 0 |
| Mono-methylation | 21 | 9 |
| Di-methylation | 8 | 1 |
| Tri-methylation | 4 | 1 |
| O-GlcNAcylation | 3 | 3 |
| Oxidation | 5 | 2 |
| Phosphorylation | 3 | 1 |
| Propionylation | 9 | 6 |
| Succinylation | 4 | 1 |
| Ubiquitylation | 10 | 1 |