Table 6.
Selected post-translational modification sites identified on the core histones and the modified peptide sequences in heat shock protein 90 inhibitor-treated bladder cancer 5637 cells.
| Modified histone site | Modified peptide sequence |
|---|---|
| Acetylation site | |
| H2BK34 | _KRKRSRK(ac)ESYSIY_ |
| H3K9 | _TKQTARK(ac)STGGKA_ |
| H3K14 | _RKSTGGK(ac)APRKQL_ |
| H3K18 | _GGKAPRK(ac)QLATKA_ |
| H3K23 | _RKQLATK(ac)AARKSA_ |
| H3K27 | _ATKAARK(ac)SAPATG_ |
| H3K56 | _EIRRYQK(ac)STELLI_ |
| H3K79 | _EIAQDFK(ac)TDLRFQ_ |
| H3K122 | _RVTIMPK(ac)DIQLAR_ |
| H4K12 | _GGKGLGK(ac)GGAKRH_ |
| H4K16 | _LGKGGAK(ac)RHRKVL_ |
| H4K20 | _GAKRHRK(ac)VLRDNI_ |
| Butyrylation site | |
| H4K20 | _GAKRHRK(bu)VLRDNI_ |
| Citrullination site | |
| H4R23 | _RHRKVLR(ci)DNIQGI_ |
| H4R55 | _LIYEETR(ci)GVLKVF_ |
| 2-Hydroxyisobutyrylation site | |
| H4K20 | _GAKRHRK(hib)VLRDNI_ |
| Malonylation site | |
| H3K122 | _RVTIMPK(ma)DIQLAR_ |
| Mono-methylation site | |
| H2AD90 | _QLAIRND(me1)EELNKL_ |
| H2BK108 | _LPGELAK(me1)HAVSGG_ |
| H3K27 | _ATKAARK(me1)SAPATG_ |
| H3K36 | _PATGGVK(me1)KPHRYR_ |
| H3K37 | _ATGGVKK(me1)PHRYRP_ |
| H3R40 | _GVKKPHR(me1)YRPGTV_ |
| H3R42 | _KKPHRYR(me1)PGTVAL_ |
| H3K79 | _EIAQDFK(me1)TDLRFQ_ |
| H3R83 | _DFKTDLR(me1)FQSSAV_ |
| H3K122 | _RVTIMPK(me1)DIQLAR_ |
| H4K20 | _GAKRHRK(me1)VLRDNI_ |
| H4R23 | _RHRKVLR(me1)DNIQGI_ |
| H4D24 | _RHRKVLRD(me1)NIQGI_ |
| H4K31 | _NIQGITK(me1)PAIRRL_ |
| H4E52 | _ISGLIYE(me1)ETRGVL_ |
| H4E53 | _SGLIYEE(me1)TRGVLK_ |
| H4D85 | _KTVTAMD(me1)VVYALK_ |
| Di-methylation site | |
| H3K27 | _ATKAARK(me2)SAPATG_ |
| H3K36 | _PATGGVK(me2)KPHRYR_ |
| H3K37 | _ATGGVKK(me2)PHRYRP_ |
| H3K79 | _EIAQDFK(me2)TDLRFQ_ |
| H4K20 | _GAKRHRK(me2)VLRDNI_ |
| H4R55 | _LIYEETR(me2)GVLKVF_ |
| Tri-methylation site | |
| H3K36 | _PATGGVK(me3)KPHRYR_ |
| H4K20 | _GAKRHRK(me3)VLRDNI_ |
| H4R23 | _RHRKVLR(me3)DNIQGI_ |
| O -GlcNAcylation site | |
| H3T45 | _HRYRPGT(og)VALREI_ |
| Oxidation site | |
| H2BY42 | _SYSIYVY(ox)KVLKQV_ |
| H3Y41 | _VKKPHRY(ox)RPGTVA_ |
| H4Y51 | _RISGLIY(ox)EETRGV_ |
| H4Y88 | _TAMDVVY(ox)ALKRQG_ |
| Phosphorylation site | |
| H2BT96 | _TSREIQT(ph)AVRLLL_ |
| Propionylation site | |
| H2AK95 | _NDEELNK(pr)LLGKVT_ |
| H2AK118 | _QAVLLPK(pr)KTESHH_ |
| H2AK119 | _AVLLPKK(pr)TESHHK_ |
| H2BK46 | _YVYKVLK(pr)QVHPDT_ |
| H3K56 | _EIRRYQK(pr)STELLI_ |
| H3K122 | _RVTIMPK(pr)DIQLAR_ |
| H4K20 | _GAKRHRK(pr)VLRDNI_ |
| H4K31 | _NIQGITK(pr)PAIRRL_ |
| Succinylation site | |
| H3K122 | _RVTIMPK(su)DIQLAR_ |
| H4K20 | _GAKRHRK(su)VLRDNI_ |
| Ubiquitylation site | |
| H2AK118 | _QAVLLPK(ub)KTESHH_ |
| H2BK46 | _YVYKVLK(ub)QVHPDT_ |
| H2BK108 | _LPGELAK(ub)HAVSGG_ |
| H3K56 | _EIRRYQK(ub)STELLI_ |
| H3K79 | _EIAQDFK(ub)TDLRFQ_ |
| H3K122 | _RVTIMPK(ub)DIQLAR_ |
| H4K31 | _NIQGITK(ub)PAIRRL_ |
| H4K77 | _TYTEHAK(ub)RKTVTA_ |
| H4K79 | _TEHAKRK(ub)TVTAMD_ |