Table 4.
Comparison of the statistically nominal significant SNP effects between children from FAMILY and adults from the Global Lipids Genetics Consortium.
| Trait | Gene | SNP | Consortium | FAMILY | Z-test | p-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | p-value | Beta | SE | p-value | |||||
| TC | ABCG5 | rs6756629 | 0.122 | 0.010 | 4.35 × 10−36 | 0.219 | 0.100 | 2.88 × 10−2 | −0.965 | 1.67 × 10−1 |
| TC | APOA1/APOA4/APOA5/APOC3 | rs12292921 | 0.096 | 0.007 | 2.22 × 10−42 | −0.193 | 0.107 | 6.99 × 10−2 | 2.695 | 3.52 × 10 −3 |
| TC | OSBPL7 | rs12452315 | 0.024 | 0.004 | 2.67 × 10−10 | 0.123 | 0.048 | 1.01 × 10−2 | −2.055 | 1.99 × 10 −2 |
| TC | LDLR | rs6511720 | 0.185 | 0.006 | 5.43 × 10−202 | 0.188 | 0.073 | 1.02 × 10−2 | −0.041 | 4.84 × 10−1 |
| TC | TOMM40/APOE/APOC1 | rs2075650 | 0.143 | 0.005 | 8.93 × 10−158 | 0.230 | 0.065 | 3.91 × 10−4 | −1.335 | 9.10 × 10−2 |
| TC | FER1LA | rs2277862 | 0.035 | 0.005 | 2.26 × 10−13 | 0.154 | 0.069 | 2.54 × 10−2 | −1.720 | 4.27 × 10 −2 |
| HDL | ATG7 | rs2606736 | 0.025 | 0.004 | 4.80 × 10−8 | −0.098 | 0.050 | 5.23 × 10−2 | 2.452 | 7.10 × 10 −3 |
| HDL | VEGFA | rs998584 | 0.026 | 0.004 | 2.27 × 10−11 | 0.094 | 0.048 | 4.87 × 10−2 | −1.412 | 7.90 × 10−2 |
| HDL | ABCA1 | rs1883025 | 0.143 | 0.053 | 7.53 × 10−3 | |||||
| HDL | LIPC | rs1077834 | 0.125 | 0.004 | 7.77 × 10−180 | 0.171 | 0.058 | 3.28 × 10−3 | −0.791 | 2.14 × 10−1 |
| HDL | CETP | rs3764261 | 0.241 | 0.004 | 1.39 × 10−769 | 0.238 | 0.052 | 5.38 × 10−6 | 0.058 | 4.77 × 10−1 |
| HDL | ABCA8 | rs4148008 | 0.028 | 0.004 | 1.13 × 10−12 | −0.139 | 0.051 | 5.85 × 10−3 | 3.264 | 5.48 × 10 −4 |
| LDL | CELSR2/PSRC1/SORT1 | rs646776 | 0.160 | 0.004 | 1.63 × 10−272 | 0.158 | 0.061 | 9.83 × 10−3 | 0.033 | 4.87 × 10−1 |
| LDL | ABCG5 | rs6756629 | 0.129 | 0.010 | 1.77 × 10−34 | 0.213 | 0.103 | 3.92 × 10−2 | −0.812 | 2.08 × 10−1 |
| LDL | APOB | rs1367117 | 0.119 | 0.004 | 9.48 × 10−183 | 0.134 | 0.053 | 1.20 × 10−2 | −0.282 | 3.89 × 10−1 |
| LDL | APOA1/APOA4/APOA5/APOC3 | rs12292921 | 0.068 | 0.007 | 7.21 × 10−20 | −0.175 | 0.110 | 1.11 × 10−1 | 2.205 | 1.37 × 10 −2 |
| LDL | BRCA2 | rs4942486 | 0.024 | 0.004 | 2.26 × 10−11 | 0.082 | 0.050 | 9.85 × 10−2 | −1.156 | 1.24 × 10−1 |
| LDL | OSBPL7 | rs12452315 | 0.025 | 0.004 | 2.37 × 10−10 | 0.114 | 0.049 | 2.17 × 10−2 | −1.810 | 3.51 × 10 −2 |
| LDL | LDLR | rs6511720 | 0.221 | 0.006 | 3.85 × 10−262 | 0.194 | 0.075 | 1.02 × 10−2 | 0.359 | 3.60 × 10−1 |
| LDL | TOMM40/APOE/APOC1 | rs157580 | 0.108 | 0.005 | 9.24 × 10−119 | 0.128 | 0.051 | 1.22 × 10−2 | −0.390 | 3.48 × 10−1 |
| TG | GCKR | rs1260326 | 0.115 | 0.003 | 2.29 × 10−239 | 0.116 | 0.048 | 1.28 × 10−2 | −0.021 | 4.92 × 10−1 |
| TG | INSR | rs7248104 | 0.022 | 0.003 | 5.05 × 10−10 | 0.138 | 0.047 | 3.28 × 10−3 | −2.463 | 6.89 × 10 −3 |
*The P-Values are for each child and adult SNP to show association effect in adults from the Global Lipids Genetics Consortium in comparison to children from FAMILY study. Beta and SE at birth, 3 year and 5 year are quartile normalization of the lipid level trait in mg/dl.