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. 2017 Mar 22;7:239. doi: 10.1038/s41598-017-00161-4

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Classical vascular analysis reveals a decrease in the number of junctions and total vessel length following TBI. (A) An axial AngioTool image where vessels (red) and junctions (blue) are displayed. Whole cortex and specific concentric radial ROIs projecting outward from the injury site (circles 1–3), were analyzed to quantify vascular alterations. TBI animals exhibited a decrease in the number of vessel junctions and length, even moving outward from the site of injury (1–3 mm). (B) Analysis of the entire whole cortex demonstrated a significant reduction in the both number of junctions (t-test, p < 0.05) and in the total vessel length (t-test, p < 0.05) in TBI animals compared to sham animals. (C) TBI animals also exhibited a significant decline in the number vascular junctions moving radially outward from the injury site (ROIs 1 to 3) (t-test, p < 0.05). A similar finding was also found in TBI animals where a significant decline in total vessel length moved radially outward from the injury site compared to sham animals (t-test, p < 0.05).