Table 3.
Association between the CYP1A1 genetic variants and the risks of colorectal cancer, colon cancer, and rectal cancer.
| CYP1A1 Genetic Variants | No. of Controls (%) | Colorectal Cancer | Colon Cancer | Rectal Cancer | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of Cases (%) | Crude OR (95% CI) | Multivariable OR (95% CI)* | No. of Cases (%) | Crude OR (95% CI) | Multivariable OR (95% CI)* | No. of Cases (%) | Crude OR (95% CI) | Multivariable OR (95% CI)* | ||
| rs4646903 | ||||||||||
| TT | 525 (37.5) | 268 (38.5) | 1.0 (ref) | 1.0 (ref) | 130 (37.1) | 1.0 (ref) | 1.0 (ref) | 133 (39.8) | 1.0 (ref) | 1.0 (ref) |
| TC | 646 (46.1) | 323 (46.3) | 0.97 (0.80, 1.18) | 0.96 (0.77, 1.21) | 156 (44.6) | 0.95 (0.73, 1.23) | 0.94 (0.72, 1.24) | 161 (48.2) | 0.99 (0.76, 1.28) | 0.98 (0.75, 1.31) |
| CC | 229 (16.4) | 106 (15.2) | 0.90 (0.68, 1.18) | 0.83 (0.61, 1.26) | 64 (18.3) | 1.10 (0.79, 1.54) | 1.04 (0.72, 1.49) | 40 (12.0) | 0.69 (0.47, 1.02) | 0.64 (0.42, 0.98) |
| rs1048943 | ||||||||||
| AA | 804 (58.6) | 422 (60.7) | 1.0 (ref) | 1.0 (ref) | 210 (60.0) | 1.0 (ref) | 1.0 (ref) | 205 (61.8) | 1.0 (ref) | 1.0 (ref) |
| AG | 483 (35.2) | 237 (34.1) | 0.96 (0.79, 1.16) | 0.95 (0.76, 1.18) | 119 (34.0) | 0.96 (0.75, 1.24) | 0.95 (0.72, 1.24) | 114 (34.3) | 0.95 (0.74, 1.23) | 0.93 (0.70, 1.22) |
| GG | 84 (6.1) | 36 (5.2) | 0.84 (0.56, 1.26) | 0.81 (0.51, 1.28) | 21 (6.0) | 0.62 (0.34, 1.14) | 0.98 (0.57, 1.68) | 13 (3.9) | 0.62 (0.34, 1.14) | 0.62 (0.32, 1.18) |
*The multivariable OR was adjusted for age, sex, BMI, education, total caloric intake, family history of colorectal cancer, and regular exercise.