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. 2017 Mar 7;7:100. doi: 10.1038/s41598-017-00176-x

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Five gene classes identified by clustering analysis exhibit distinct epigenetic features. (a) Box plots comparing levels of histone marks, NLA, and gene activity among the five gene classes in C2C12 myoblasts. “pr” and “gb” represent promoter regions and gene bodies, respectively. The minimum and the maximum values are presented by whisker ends and quartiles by box boundaries. For all variables, Mann-Whitney tests revealed significant differences (FDRs < 0.05) between every pair of the five classes. (b) Heat maps of Pol II, histone marks and NLA across genic regions. Genes in each class are sorted by decreasing gene activity. Vertical red bars on the left mark active genes (18.58%, 33.95%, 69.88%, 98.50% and 99.97% of Class I to V, respectively). Horizontal black bars at the bottom mark annotate transcribed regions from TSS to TES. Data are binned as described in Fig. 3b.