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. 2017 Mar 7;7:84. doi: 10.1038/s41598-017-00167-y

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Conventional voxel-wise multi-pool Lorentzian fitting versus Image Downsampling Expedited Adaptive Least-squares (IDEAL) fitting in the two-compartment phantom (left: 50 mM Creatine (Cr) and 100 mM nicotinamide (amide); right: 100 mM Cr and 50 mM amide) with different levels of Gaussian noise added. (a) Multi-pool Lorentzian fit of the global Z spectra at different noise levels to determine initial values for IDEAL fitting. The global Z spectrum was obtained by averaging the Z spectra of all voxels within the phantom. (b) Fitted amide and Cr maps using conventional fitting or IDEAL fitting. The corresponding R² maps were shown.