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. 2017 Mar 2;7:113. doi: 10.1038/s41598-017-00155-2

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© The Author(s) 2017

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Unexpected hERG activation by S4-S5_L (0) peptide is not reinforced by its covalent binding though a disulfide bond. (A) Top, representative, superimposed recordings of the L666C hERG current in the presence of E544C S4-S5_L (0) peptide (1 µg L666C hERG plus 3 µg peptide plasmids) after 2 h incubation in Tyrode without (control) or with 0.2 mM tbHO₂ (tbHO₂), using the protocol shown in (B). Bottom, corresponding mean hERG tail-current density at −40 mV after a prepulse at +100 mV. (B) D540C S4-S5_L (0) peptide same as in A.