Figure 2.

Kinetic characterization of [³H]INCB3344 in murine CCR2. Association and dissociation kinetics of 5 nM [³H]INCB3344 binding to membranes of CHO cell membranes transiently expressing murine CCR2 at 25 °C. Dissociation was initiated by the addition of 10 µM INCB3344. Association and dissociation data were fitted using a monophasic exponential association, or exponential decay model, respectively. Graphs shown are representative from one experiment performed in duplicate. Data for all association and dissociation experiments (n = 3) are presented in Table 1.