Figure 5.

Inhibition of lesion development in the carotid artery by 15a. (a) The CCR2 antagonist 15a significantly reduced atherosclerotic plaque size in the carotid artery at the site of maximal stenosis. (b) Similarly, plaque volume, given as plaque size at increasing distance from the collar and (c) as total volume in µm³ was significantly reduced by 15a. Micrographs show representative images of the individual groups (100X magnification). *P < 0.05, **P < 0.01, ***P < 0.001. Graphs shown are representative from one experiment with n = 10 controls versus n = 9 15a-treated mice.