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. 2017 Mar 13;7:168. doi: 10.1038/s41598-017-00120-z

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© The Author(s) 2017

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Effect of RNAi against TAR2 and TAR3 on a TAR2 mutant background. (A) Representative responses to 1000 nM TA from c42-gal4 TAR2 ^f05682 /TAR2 ^JF01878 TAR2 ^f05682 (upper trace) and c710-gal4 TAR2 ^f05682 /TAR2 ^JF01878 TAR2 ^f05682 (lower trace) tubules. (B) Representative responses to 1000 nM TA from c42-gal4 TAR2 ^f05682 /TAR3 ^JF02749 TAR2 ^f05682 (upper trace) and c710-gal4 TAR2 ^f05682 /TAR3 ^JF02749 TAR2 ^f05682 (lower trace) tubules. (C) Mean responses to 1000 nM of the four genotypes shown in (A and B). Knockdown of both TAR2 and TAR3 in the stellate cells caused a significant reduction in the response compared to knockdown in principal cells, p < 0.05, 1-way ANOVA and Sidak’s multiple comparisons test, but only knockdown of TAR3 in the stellate cells resulted in a mean response that was equal to zero, p = 0.45, 1-sample t-test. n = 8–9 tubules per genotype.