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(a) mtDNA content in urine. (b) mtDNA common deletion mutation in urine. ART, antiretroviral therapy; ART+TDF+, TDF treated; ART+TDF−, treated with non-TDF therapy; ART−, antiretroviral naive; CD, common deletion; mtDNA, mitochondrial DNA; TDF, tenofovir disoproxil fumarate.
Dotted line at −5.7 log10 copies/mtDNA corresponds to lower limit of assay. ND, not detected. Note: On each plot, dots represent individual study participants.
