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. 2017 Mar 10;7:141. doi: 10.1038/s41598-017-00207-7

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© The Author(s) 2017

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The expression of neuregulin 1 (NRG1) and ErbB4 in human symptomatic epileptic tissues. (a) Immunoblotting shows increased ErbB4 and NRG1 protein expression in the temporal cortex of symptomatic epilepsy patients. (b) Quantification of NRG1 and ErbB4 immunoblots (n = 12). (c) DAB staining shows increased ErbB4 immunoreactivity in symptomatic epileptic tissues. (d) Representative western blots of ErbB4 in cavernoma patients with and without symptomatic seizure and epileptiform discharge. Cavernoma patients without symptomatic seizure and epileptiform discharge (CA). *P < 0.05; ***P < 0.001. Unpaired two-tailed Student’s t-test. Data are represented as the mean ± s.e.m.