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. 2017 Mar 10;7:141. doi: 10.1038/s41598-017-00207-7

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Src kinase is regulated by NRG1-ErbB4 signaling in the human brain. (a) NRG1 decreased the phosphorylation of Src at Y416 in the human temporal cortex. (b) Statistical analysis of phosphorylated Src at Y416 (n = 8). (c) Ecto-ErbB4 (2 μg/ml) treatment markedly increases Src-pY416 in the human brain. (d) Quantification of Src-pY416 immunoblots (n = 5). *P < 0.05. Unpaired two-tailed Student’s t-test. Data are represented as the mean ± s.e.m.